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This suggests that the association between B12 concentration and homocysteine is modified by TC 776 genotype and that plasma homocysteine concentrations may be more responsive to dietary B12 or B12 supplements in carriers of the 776CC reference compared with carriers of the 776GG variant.
Based on age-specific relative risks, we estimated that there could be at most 796 BRCA1 (1.7%) and 433 BRCA2 (0.9%) undetected carriers in the reference dataset of 47,565 BCAC cases.
We observe that there is no correlation between the subcarrier of reference and other carriers which are spaced from it at a distance equal to a multiple of N p L h.
Considering the intermediate-risk group as the reference group, carriers of <3 alleles had a lower risk of MI, while carriers of >7 alleles had an increased risk (Figure 2).
This accords with meta-analysis studies which have found it difficult to identify any statistically significant risk differences between the carriers of ε2 allele and the reference ε3ε3 genotype, unless a large number of cases is available, mainly due to the low frequency of ε2 in the populations considered [15].
Newborn screening for SCD identifies all carriers of structural haemoglobin variants (screening identifies carriers of 'unusual haemoglobins' of which the most common is Sickle Cell; for ease of reference, SCD is used in this paper when referring to all unusual haemoglobins detected by screening) but not thalassaemia carriers and there is no available method of testing without detecting carriers.
In wild type cultures, this stimulation elicited instantly sinusoidal optical signals of Vf2.1.Cl fluorescence at the frequency ν of the carrier wave (reference frequency) in virtually all cells of the network within the field of view (Additional file 1: Movie S1).
A genotypic model was used to determine the risk associated with carrying one or two rare alleles, using homozygote carriers of the frequent allele as a reference.
The largest group (the carriers of the A-allele) was used as reference, in order to obtain the most precise estimates.
Carriers of DR1/DR2, a common genotype in the reference population and of DR2/DR6, had virtually no risk of T1DM before the age of 15, with a predictive probability for T1D free survival very close to 1.
c) CI: 95% confidence interval d) P: trend test e) The genotype serves as reference category f) Homozygous carriers of the haplotype compared to the rest.
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