Sentence examples for carrier strain from inspiring English sources

This includes the choice of heterologous protective antigens and their expression under the control of appropriate promoters within the carrier strain.

Furthermore, the intracellular-activated promoter was more efficient in combination with a carrier strain deficient in SPI2 gene sseC than with the conventional aroA strain.

A ΔyopP mutant-based vaccine carrier strain induced the highest numbers of LLO91 99-specific CD8 T cells and effectively protected mice against a lethal challenge with Listeria whereas ΔyopPT, ΔyopPVK42Q, and ΔyopPO mutants of Y. enterocolitica induced fewer CD8 T cells and conferred only partial protection.

Importantly, our model carrier strain (D30) was on the same clade as was the model non-carrier strain (930918-3).

First, the carrier strain may have been derived from the outbreak strain.

A similar trend was seen for the intermittent carrier strain 502-A (0 of 18).

We investigated the performance of an intracellular-activated promoter for expression of heterologous antigens by Salmonella carrier strains.

Likewise, attenuated Y. enterocolitica live carrier strains were reported to induce both CD8 and some CD4 T cell responses.

Here, we review recent advances in generation of live attenuated Salmonella vaccines and discuss criteria for expression strategies of heterologous antigens by Salmonella carrier strains.

This allows the rationale design of improved Salmonella carrier strains and the development of novel strategies for the expression and presentation of recombinant antigens.

The ability of carrier bacteria to persist and/or to lyse in the gastrointestinal tract needs to be considered to design optimal carrier strains to deliver proteins of interest at the mucosal level.