Nevertheless, sensitivities of prediction tools in separating carriers from non-carriers are moderate at best: e.g. Robicsek et al. presented models with comparably good discriminatory ability, which nevertheless missed at least 32% of carriers within the validation cohort even if 30% of admissions were screened [ 11].
Although only some of these variants were associated at P <0.05 with breast cancer in mutation carriers as outlined above, there was nevertheless strong correlation between the HRs for overall breast cancer from the general population and those from BRCA2 carriers, and moderate correlation between the HRs from BRCA1 carriers and from BCAC.
About 1/3 of carriers have moderate to severe liver fibrosis and 60% have detectable aflatoxin-related TP53 R249S mutation.
The estimated BC hazard ratios (HRs) for the 74 known BC alleles in BRCA1 carriers exhibited moderate correlations with the corresponding odds ratios from the general population.
Although the association between visual failure and heavy alcohol consumption was not statistically significant in the logistic regression analysis, it would also seem sensible for LHON mutation carriers to moderate their alcohol intake and avoid binge drinking episodes.
The antiferromagnetic semiconductor phase is quite robust against moderate carrier filling with threshold carrier density up to 1.7 × 1014 electrons/cm2 to destabilize the phase.
Interestingly, a weakly negative permittivity behavior was observed in the measured frequency, showing small negative values of permittivity between −50 and −10, which was ascribed to a moderate carrier concentration provided by the carbon networks.
Similarly, for gene transfection to be effectively performed, required is a carrier that exhibits moderate levels of cytotoxicity, able to rupture and penetrate the cell membrane prior to releasing the therapeutic agent targeting the nucleus.
We could find a risk decreasing genetic effect for C-carriers only for moderate smokers (OR = 0.2, 95% CI 0.1 0.7, p = 0.012).
The electrical features obtained from Van der Pauw Hall measurements show enhanced charge carrier mobility, resistivity and moderate charge carrier concentrations.
OVA co-delivered with biomaterial carrier vehicles supported a moderate humoral immune response that was maintained for the 18-week duration of the experiment.
