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Missing data were handled using a combination of complete case analysis and last observation carried forward methods.
Sensitivity analyses performed for the primary endpoint in the PPS (using observed values and worst observation carried forward methods, and considering all dropouts and treatment failures to be non-responders) demonstrated the same results as those in the primary analysis of the PPS using last observation carried forward (data not shown).
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Missing data were treated with the last observation carried forward method.
In addition, any missing value will be replaced by the previous value according to the last value carried forward method.
A last observation carried forward method was used to impute missing values within a single headache diary attack.
In case of incomplete or missing follow-up data, the last observation carried forward method (LOCF) was used [17].
As noted above, missing data was replaced using the last observation carried forward method.
All analyses were intent-to-treat, and missing data were replaced using the last observation carried forward method.
* Missing values imputed by last observed value carried forward method.
Analyses were performed using the last observation carried forward method.
For missing data the last observation carried forward method was used.
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