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Second, the screening policy changed during the study period, possibly explaining the lack of increasing ESBL-PE incidence density carriage over time.
Longitudinal studies are needed to assess the variation of asymptomatic parasite carriage over time, and its exact contribution to transmission.
For that reason, results from this study need to be confirmed in a longitudinal study in which occurrence of MRSA carriage over time is associated with the use of antibiotics and other determinants.
However, to understand better the dynamics of SA nasal carriage over time, longitudinal studies are required.
Our longitudinal study design allowed us to investigate carriage over time.
Changes in prevalence of bacterial carriage over time will be plotted for NPS in mothers and newborns, and breast milk.
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The prevalence of particular hyperinvasive lineages in carriage changes over time, and this is reflected in the rates of disease that they cause.
Longitudinal monitoring of 61 carriers (both persistent and intermittent) revealed variations in the STs of SA nasal carriage strains over time.
Changes in MRSA carriage in pigs over time were significantly associated with changes in antimicrobial use; the odds for a 2-fold increase in antimicrobial use per sampling time (antimicrobial use time interaction) decreased from the second to the last sampling (ORs 0.94, 1.27, 1.26, and 1.14 in the 4 consecutive samplings; p = 0.01).
Overall, this study indicates that colonizing strains of SA are not specific to a particular host or carriage type (i.e., persistent versus intermittent carriers) and both carriage type change strains over time, suggesting that other non- SA factors could be contributing to specific carriage states.
The prevalence of asymptomatic carriage of asexual parasites over time is presented in Table 1.
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