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This genetically diverse collection was comprised of nasopharyngeal or throat isolates from healthy children (collectively analyzed as the "carriage group") (n = 92), middle ear (n = 94), blood (n = 83), and cerebrospinal fluid (n = 57).
The median age of persons in which skin infections developed in the first year was 17 years and was similar for each carriage group (p = 0.50).
Five PVL-positive S. aureus strains (0.6%) were found in the carriage group (n = 829), and 3 (2.1%) of 146 blood-culture isolates carried the PVL gene (Table).
No difference was detected in the numbers of skin infections by sex and carriage group in either analysis of the first year (p>0.3) or the full study period (p>0.9).
The estimated length of time for 50% of the MRSA carriage group to have developed a skin infection was 289 days (0.8 years), 1,049 days (2.9 years) for MSSA carriers, and 804 days (2.2 years) for non– S. aureus carriers.
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†χ tests were used to detect differences in carriage groups by sex and household member status; nonparametric 1-way analysis of variance software (SAS Institute, Cary, NC, USA) was used to detect differences in carriage groups by age.
The log-rank statistic was used to compare survival (time without a skin infection) between carriage groups.
Shouval et al. [ 40] showed that PCV13 extended the coverage to 79% of acute otitis media and 67% of carriage groups versus 54% and 46% respectively, with PCV7.
MRSA was the cause of 90% of skin infections in the follow-up period, with a similar proportion of cultures obtained among the carriage groups.
Univariate analyses were performed to compare demographic and clinical characteristics among 3 carriage groups (MRSA, MSSA, and non– S. aureus infections).
However, in this study antimicrobial drug use did not differ among the 3 carriage groups and thus was not associated with subsequent risk for disease from MRSA.
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