The nanovectors released large protein cargos in aqueous solution under acidic pH or magnetic stimuli.
Our adaptations provide genetic-level control over the densities of motor proteins coupled to, as well as the sizes of endogenous vesicular cargos in these assays.
In addition to drugs that may be active cargos in SLNs, some natural compounds with pharmacological activity are also suitable for SLN encapsulation to enhance oral bioavailability.
We compared the motility of kinesin-1-driven cargos in the absence and presence of Myo1c at engineered actin/microtubule intersections.
The innate biological RLNs induced efficient intracellular trafficking of cargos in situ via multi-targeting mechanisms, including scavenger receptor class B type I (SR-BI -mediated direct tranSR-BI -mediatedery, aSR-BI -mediated lipoprotein-receptors associatedirectcytransmembrane
We believe that the hydrogel patch fabricated in this study will be highly useful to better understand a broad array of complex biological processes and also improve the efficacy of molecular cargos in varied applications.
