Exact(1)
Like ParA proteins involved in cargo partitioning, Soj forms ATP-dependent dimers that bind DNA in vitro (Scholefield et al., 2011) and display nucleoid-associated localization in cells lacking Spo0J (Murray and Errington, 2008).
Similar(59)
CLSM images show how NTR⋅cargo complexes of different sizes and NTR-to-cargo ratios partition between FG phase and bulk solvent.
In the first one, we consider the barrier as a 'solvent', into which NTRs, but not inert cargo domains, easily partition.
In this model, enzymes and transmembrane cargo not only rapidly partition between two lipid phases but also exchange fast among cisternae.
A complete NTR-assisted partitioning of the cargo into the FG phase would then be an essential stage during a successful NPC passage.
Diverse classes and shapes of materials have been investigated to establish design principles that achieve the effective partitioning of medical cargos between tumors and healthy tissues.
DOI: http://dx.doi.org/10.7554/eLife.04251.017 10.7554/eLiFigure513 Figureure 13—Figure supplement 1. Partitioning of various NTR cargo complexes into TtMacNup98 FG particles.
Since ParA-like proteins are implicated in the partitioning of various cytoplasmic cargos, the conservation of their DNA-binding activity suggests that the DNA-relay mechanism may be a general form of intracellular transport in bacteria.
A removable partition on the main deck separated the cargo area at the rear from the passengers at the front.
Along with the usual luggage cover, a partition net is easily raised to isolate the cargo area.
Additional NTR molecules should minimise this penalty by further reducing the cargo's accessible surface area and by their own propensity to partition into the FG gel.
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