Sentence examples for cargo accumulation from inspiring English sources
To examine whether ENA down-regulation could give rise to abnormal cargo accumulation, the localization of the synaptic vesicle protein CSP in the larval segmental nerves (Fig. 6B) was examined [25], [41].
As p62 is degraded by autophagy alongside its cargo, accumulation of p62 indicates disrupted autophagic degradation.
10.7554/eLife.00459.021 Figure 5. Cargo accumulation at the PM is toxic during heat stress.
Together, these data suggest that Vha44 overexpression impairs endolysosomal degradation leading to cargo accumulation in enlarged late endosomes and/or lysosomes.
Recently, reductions in kinesin in vivo have been reported to exacerbate tau-induced axonopathies and cargo accumulation (227, 228), consistent with our findings.
Interestingly, the opposite was observed for active transport in the presence of RanGTP, where net nuclear cargo accumulation was reduced for Δ15370% nuclei.
Finally, a number of cells also showed an increase in PDI levels (Figure 2G), probably reflecting the ER accumulation of cargo proteins leading to increased unfolded protein response.
Accumulation of cargo proteins along the secretory pathway often results in dilation of respective intracellular compartments.
First, accumulation of cargo brought in via macroautophagy at the lysosomes without its efficient degradation.
Failure of autophagy leads to accumulation of cargo and autophagy substrates such as p62/SQSTM1, NBR1 and tau.
Conversely, when GEF activity is inhibited the constitutive-like release is inhibited, resulting in the accumulation of cargo in MSGs above even normal levels.
