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All three epidemiologic studies had careful prospective designs and measured a variety of important potential confounders.
However, there were limitations to these studies and additional careful prospective studies are required to address this important issue.
However, using a logistic regression model directly as a signal detection algorithm brings challenges that will need careful prospective evaluation.
By careful prospective measurement of ambulatory blood pressure in living kidney donors before and after nephrectomy, this study will also provide important practical information needed for patient care.
Some editors [ 6] have found that even careful, prospective research cannot reliably identify characteristics of good reviewers, ways to train reviewers to become better, or characteristics that contribute to good reviewing skills.
Further investigations of newly diagnosed epilepsy patients with distinct epilepsy syndromes including careful prospective study designs with longitudinal follow-up of the same patient groups would be beneficial to identify more clear understanding of neuropsychological, behavioral, academic/learning problems of these patients.
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New studies in HF populations with careful and prospective characterization of diabetic patients are needed; these studies may be designed either as ancillary studies of prospective randomized trials or as part of prospective registries on HF.
The strengths of the TODAY clinical trial were enrollment of participants soon after diagnosis of type 2 diabetes, administration of early aggressive therapy for type 2 diabetes, hypertension, and microalbuminuria, and the careful, comprehensive, prospective monitoring of subjects over 2 6.5 years of follow-up.
Shortly after, Aberdeen's Chris Fishwick and Piers Currie warned: "Marketers of splits have to be careful to target prospective investors for whom geared risk is suitable rather than novice investors who do not understand the product".
Mr. Morris, whose $10 million fund operates in both Cambodia and Laos, says he has been "incredibly careful" in identifying prospective business partners and has so far found just two in which he hopes to complete investments this summer.
They do this by putting significant investment into "effective advice and guidance at the entry stage," says Mills, explaining that the Regional Centres employ staff whose job it is to give careful counselling to prospective students.
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