One of the possibilities is to speed up the melanopsin response through careful mutations.
This type of analysis has not been provided by other quality-control softwares, however, it would be particularly useful for careful examination of mutation finding from a high coverage data, to improve analyses of, e.g., somatic mutations, cancer cells, or mitochondrial heteroplasmy.
Careful analysis of the mutations reported in p53 mutation databases also provides corroborating evidence that the high incidence of GC > AT mutations in the p53 gene, observed in lung cancer, might also be related to non-CpG methylation, as well as to the overall increase of methylation sites in this locus.
Careful comparison of APC mutation and silencing in well-defined model systems is required to address this issue.
Although common disorders are normally considered as lacking a major mutation, a careful consideration suggests that this view is inaccurate.
Indeed, the careful examination of HD mutation carriers has revealed a variety of subtle effects (such as cognitive, motor and sensory changes, as well as inflammatory markers) that are detectable many years before clinical diagnosis [ 4- 8].
Careful scrutiny of the TCGA mutation data revealed that six mutations were localized in the second zinc finger and five of them were frameshifts, similar to the mutation in MCF7 [ 23], making MCF7 a useful model to study a clinically relevant phenomenon.
Patients with PTRF mutations require careful anesthetic planning.
The regionally distinct phylogenetic patterns and certain drug-resistance mutations necessitate careful application of novel diagnostics and empiric therapeutic strategies.
Therefore, analyzing single-point mutations requires careful and comprehensive manual considerations in multiple aspects involving chemical properties of specific amino acid residues as well as those of the whole protein.
