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Gaps in the evidence include the need for longitudinal studies with stronger causal designs – for example, examining changes in RD in relation to changes in health outcomes, with careful control for confounding by individual income and other indicators of socioeconomic position.
Evidence that higher family income is a significant predictor of whether a woman decides to seek reconstructive surgery [ 4] emphasizes the need for careful control for associated parameters.
The strengths of this study include a large sample size, a prospective cohort design, and careful control for established and potential risk factors for death.
We hope our results will stimulate further evaluation of CVD incidence and mortality in dioxin-exposed cohorts, especially using internal comparisons with detailed exposure assessments, and careful control for confounding.
A better understanding of the underlying biologic pathways involved in the association between PA and breast cancer outcomes could be gained with a sufficiently powered study using more accurate measures of body fat, valid measures of PA, and careful control for patient and tumor-related moderators of the effects of PA on breast cancer outcome.
Nonetheless, the investigation of fetal pathologies such as T18 and T21 cannot be fully replicated in other organisms, and these results suggest that epigenetic changes between disease groups can be identified, as long as there is careful control for all confounding factors such as gestational age and consideration of the effects of tissue composition.
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In a general intensive care population, after careful controlling for confounders, hyperchloremia was significantly associated with increased 30-day ICU and hospital mortality.
These results underscore the importance of careful controls for possible life span effects on the conditional gene expression system itself, independent of the specific identity of the gene being over-expressed.
A number of different self-assembly techniques (bottom-up) have been used to synthesize the QDs, and they may be broadly subdivided into wet-chemical and vapor-phase methods [22]: (a) wet-chemical methods mainly follow the conventional precipitation methods with careful control of parameters for a single solution or mixture of solutions.
This variability clearly shows both the need for optimisation and for careful control of process conditions.
Different types of reference sequences, with similar phenotypes and/or with exact or nearly exact mononucleotide and dinucleotide base composition as the real pre-miRNA, can be easily generated for miRNAs, allowing for careful control of the effects of secondary structure evolution.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com