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CHEM, chemiluminescence; TBLU, toluidine blue retention; CHTB, toluidine blue retention and chemiluminescence; HPMV, histopathology majority vote; LCA, latent class analysis; HRL, high risk lesion We made three cardinal observations.
The association of tumor-infiltrating T-cells and their well-defined correlation with clinical outcomes in ovarian, breast, prostate, renal, esophageal, colorectal carcinomas, and melanomas were cardinal observations in the understanding of the role that immunology plays in cancer [ 41- 47].
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Another cardinal observation of this study is that the effects of the neonatal injury were global.
Most documented studies also have their cardinal observation as the vast majority of cases being non-idiopathic, with percentages of 83.3% [ 19], 86.4% [ 4], 90% [ 5], 90.9% [ 9] and 93% [ 2] having been reported.
Observations that this cardinal "Th1-driven" disease was independent of either IFN-γ or IL-12 2, 3, led to the appreciation of the indispensible role of IL-23 4 and, ultimately, to the characterization of the IL-17-producing, ROR-γt-expressing, Th17 subset and its importance in EAE 5.
How unfortunate that, in presenting the award for best director during the Academy Awards ceremony, Ben Affleck chose to quote Frank Capra's observation that "the cardinal sin is dullness".
The following cardinal rules should be observed.
Replication of experimental results with validation by different observers is a time-honored cardinal scientific principle supporting the reliability of a scientific observation [ 39].
Cardinal Edward M. Egan was kept for observation at St . Vincents Hospital Manhattan in Greenwich Village for a third night on Monday.
On the other hand, the previous observation that BOLD responses to cardinal orientations are lower than those to other orientations is less straightforward as far as interpretations are concerned.
Observations of a Bilateral Gynandromorph Northern Cardinal (Cardinalis cardinalis), The Wilson Journal of Ornithology, 126 (4) 778-78126
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