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More recently, an interaction between FGF and activin, mediated by phosphorylation of p53, has been implicated in mesoderm specification in Xenopus [59], but a cardiac role for this mode of regulation has not been investigated.
A cardiac role for miR-21 has been attributed to its function in fibroblasts by Thum et al. [ 100].
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Physiologic and cardiac roles of beta-arrestins.
Due to the lethal phenotype of mice with combined deficiency in Mena and VASP, however, distinct cardiac roles of the proteins remain speculative.
PKD (protein kinase D) is a serine/threonine kinase implicated in multiple cardiac roles, including the phosphorylation of the class II HDAC5 (histone deacetylase isoform 5) and thereby de-repression of MEF2 (myocyte enhancer factor 2) transcription factor activity.
Thyroid hormone plays an important role in cardiac function.
Using this system, we eliminate a rare EGFP-expressing cell type in the heart and demonstrate its role in cardiac function.
Cardiac two-pore domain potassium channels (K2P) exist in organisms from Drosophila to humans; however, their role in cardiac function is not known.
It mediates the vasodilator effect of Ang-(1 7) playing an important role in cardiac function [ 34].
Protein kinase C plays an important role in cardiac function, calcium metabolism, and contractility.
OB plays a significant role in cardiac function in humans, both under physiological and pathological conditions.
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