The definition of cardiotoxicity in both studies was based on the Cardiac Review and Evaluation Committee's (CREC) criteria of drug-associated cardiotoxicity: a reduction in left ventricular ejection fraction (LVEF) of ≥5 to <55% with symptoms of heart failure (HF) or an asymptomatic reduction of LVEF of ≥10 to <55% [4, 5, 24].
A pulse rate consistently above 120/min should be a signal for a cardiac review.
Recent studies have demonstrated that myogenic transcription factors such as serum response factor (SRF), MEF2c, and MyoD control the expression of myomiRs in skeletal and cardiac muscles (reviewed in [35]).
An expert cardiac pathologist reviewed slides of the myocardial tissue.
Conversely, inhibition of Wnt/frizzled signaling pathway seems also to have beneficial effect on cardiac remodeling (reviewed in [ 66, 67]).
Overall, blockage of Wnt signaling by targeting distinct pathway elements has a beneficial effect on cardiac remodeling (reviewed in [ 66, 67]).
The epicardium is also the main source of cardiac fibroblasts (reviewed in (Souders et al., 2009), prior to EMT the whole epicardium expresses Tcf21, which is necessary but not sufficient for fibroblast fate specification (Acharya et al., 2012).
In this regard, remote ischemic preconditioning (RIPC) may offer a novel noninvasive and virtually cost-free treatment strategy for decreasing AKI incidence in patients undergoing cardiac surgery (reviewed by Hausenloy and Yellon ).
Symptoms of C. fleckeri envenoming can include the rapid onset of severe cutaneous pain and inflammation, dermonecrosis, dyspnoea, transient hypertension, hypotension, cardiovascular collapse and cardiac arrest (reviewed in [ 1]).
With its implicated roles ranging from viral infection and cancer to liver and cardiac diseases (reviewed in [73]), autophagy's importance in the maintenance of health is just beginning to be realised.
Hypertrophic cardiomyopathy (HCM) is considered to be the most frequent inherited disease of the myocardium and thought to be caused by point mutations in genes encoding proteins of the cardiac sarcomere (reviewed in [ 39]).
