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Therefore, functional study of the κ-opioid receptor on human cardiac preparation is necessary.
To the best of our knowledge these findings in the present study have not been reported in any other mammalian cardiac preparation.
Collectively, these findings describe the anti-arrhythmic efficacy of HERG and KATP K+ channel activation in the setting of hypokalaemia for the first time in any cardiac preparation.
To the best of our knowledge this is the first report documenting these differential anti-arrhythmic effects of CaMKII inhibition in any cardiac preparation.
These findings show for the first time in any mammalian cardiac preparation the pharmacological separation of EADs from an arrhythmic substrate, demonstrating the importance of both EADs and arrhythmic substrate in the initiation of arrhythmias at the whole heart level.
Nevertheless, this study shows for the first time in any cardiac preparation that activation of HERG and KATP K+ channels is an effective anti-arrhythmic approach in the murine heart in the setting of the common clinical condition of hypokalaemia, findings, which at the very least merit further testing.
Similar(53)
The tools and analysis are not limited to cardiac preparations, but are applicable for dynamic fluorescence imaging in networks of any excitable media.
Although both aggregates had a 100% success rate in pacing quiescent cardiac preparations, Cx43-ESdCs had an increased likelihood of gaining pacemaker dominance (Cx43: 40% vs. WT: 13%) in spontaneously active preparations.
We describe novel mechanistic insights relating to the action of HCQ in cardiac preparations.
Others report a direct positive inotropic response in isolated cardiac preparations [ 60, 80].
One of the remaining challenges is the variability of data recorded in cardiac preparations of many different types.
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