At sublethal doses, TCDD is carcinogenic and causes a wasting syndrome and defects in cardiac contraction.
Pointon, A. et al. From the Cover: High-Throughput Imaging of Cardiac Microtissues for the Assessment of Cardiac Contraction during Drug Discovery.
Calcium is an important effector of the coupling between cardiac depolarization (excitation) and cardiac contraction (called "excitation-contraction coupling").
Activation of beta-receptors increases heart rate and stimulates cardiac contraction (thereby increasing cardiac output), dilates the bronchi (thereby increasing air flow into and out of the lungs), dilates the blood vessels, and relaxes the uterus.
Gap junctional communication (GJC), mediated by the connexin protein family, allows this type of intercellular crosstalk resulting in synchronized and cooperative tissue behavior such as cardiac contraction.
This study provides evidence on the dietary Zn-supplementation-induced transcriptomic signature in sheep, that mainly reflects transcriptional-modulation, induced immunity, and disrupted cardiac contraction patterns.
They generate the rhythm, coordinating and controlling cardiac contraction.
Therefore, rPEP could use an alternative parameter for left cardiac contraction performance instead of qPEP under various clinical setting.
Spearman's rank correlation coefficient and Blant-Altman analysis was used to evaluate the ability for the left cardiac contraction performance.
Using the LV pressure waveform as a marker of cardiac contraction, data were acquired during hypoxia until either sustained irregular ventricular contractions or acute systolic pump failure occurred.
In contrast, many genes involved in maintaining normal heart functions such as cardiac contraction and heart rate regulation were down-regulated.
