Sentence examples for cardiac commitment from inspiring English sources

This work may represent a new approach to induce both resident and non-resident stem cells to cardiac commitment in a 3-D structure, without using additional stimuli.

qPCR and immunofluorescence analyses showed the ability of this construct to direct initial MSC and NMC lineage specification towards cardiomyogenesis: both MSCs and NMCs showed the expression of the cardiac transcription factor GATA-4, fundamental for early cardiac commitment.

As shown previously, inhibition of the IGF-1-mediated signaling pathway abolishes cardiac commitment in ES cells without affecting endothelial cell formation [11,21].

Accordingly, in order to enhance MSC cardiac commitment and therapeutic potential, PL could substitute the numerous current attempts to design cocktails of soluble molecules and factors [ 55, 56] by a more standardized, safe, and reproducible method.

It has been reported that PI3K signaling induces cardiac commitment in ES cells, suggesting that activators of this kinase such as IGF-1, TGFbeta, FGF, and insulin may promote cardiogenesis in vitro [18].

However, protocols need to be developed and optimized to ensure the purity of MiPS-CP and determination of the level of differentiation of MiPS towards cardiac commitment would ensure better prognosis.

The present cell culture and analysis of mRNA expression revealed that cardiac lineage commitment of Sk-34 cells was accelerated association with active commitment to skeletal and smooth myogenic lineages after culture, but multinucleated skeletal muscle cells were scarcely observed after freshly isolated Sk-34 cell transplantation.

Decades of research in developmental biology have revealed the fine balance of transcription factor expression that is required to initiate and maintain cardiac lineage commitment.

As an initial step, exposure of pluripotent ESCs to cardiopoietic factors was found to enrich genomic programs towards cardiac lineage commitment [27].

The specific expression pattern of sik1 during mouse development prompted us to investigate the role of sik1 in the regulation of cardiac lineage commitment in a stem-cell model system.

In this review, we provide a comparative synopsis of the major signaling pathways required for cardiac lineage commitment in the embryo and murine ESCs.