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The clinical management of prostate cancer requires the identification of the so-called Gleason patterns in the biopsies [40], which after almost fifty years is still "the sole prostatic carcinoma grading system recommended by the World Health Organization".
Carcinoma grading was performed as described [ 38].
The mammary carcinoma grading was assessed in respect to tubule formation, degree of differentiation and mitotic index.
The tumor s were histopathologically classified as follows: BCSC#1 is an invasive ductal carcinoma, grading G2, ER 90%, PR 60%, HER2/neu 3+ and ki67 >10% BCSC#2 is an invasive ductal carcinoma, grading G2, ER 90%, PR 60%, HER2/neu 3+ and ki67 25%, BCSC#3 is an invasive ductal carcinoma, grading G2, ER 80%, PR 80%, HER2/neu 3+ and ki67 >10%.
The mammary carcinoma grading was assessed in respect to tubule formation, degree of differentiation and mitotic index as grade I, grade II, or grade III tumor.
Diagnoses were: two oncocytomas, one papillary carcinoma (grading G1), one chromophobe carcinoma (G2) and 20 clear cell carcinomas (12 G2, eight G3).
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Microbiopsy demonstrated poorly differentiated invasive ductal carcinoma (grade II, low MI, HR+, HER2-).
The dysglossia study cohort (OC) comprised 49 patients (14 females and 35 males) after treatment of oral squamous cell carcinoma, graded T1 to T4.
Human breast cancer samples were classified into fibro-adenoma (FAB), lactating benign fibro-adenoma (LFAB), Infiltrating Ductal Carcinoma Grade I, II and III (IDC G I, II and III) by standard HE staining.
In breast cancer, statistically significant overexpression correlated with carcinoma grade.
The tumor tissue 'Conventional Renal Cell Carcinoma, Grade 2' and 'Conventional Renal Cell Carcinoma, Grade 3' showed the highest concordance κ = 0.77, followed by 'Breast Carcinoma' and 'Breast Carcinoma Invasive Ductal Carcinoma, Grade 2' (κ = 0.74) and 'Breast Carcinoma Invasive Ductal Carcinoma, Grade 2' and 'Breast Carcinoma Invasive Ductal Carcinoma, Grade 2' (κ = 0.70).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com