Exact(8)
Carcinogenicity (potential to cause cancer) studies are generally required if humans will use the drug for longer than six months.
Carcinogenicity potential for 2,579 (26%) of these chemicals has been evaluated by at least one source.
Animal models of mutant TP53 are invaluable for basic cancer research, the development of cancer therapeutics and screening compounds for carcinogenicity potential.
In light of the bias of chemical testing for carcinogenicity potential, a section in this chapter is devoted to the current theories of carcinogenesis.
This article is in response to the challenge issued to the scientific community by the National Toxicology Program to predict the carcinogenicity potential of 30 chemicals previously selected for long-term carcinogenicity testing.
The finding of significant associations between HPV 16/18 seropositivity and lifetime history of cancer adds epidemiological evidence to the carcinogenicity potential of HPV 16 and 18 on other tissues in addition to anogenital and oropharyngeal sites.
Similar(52)
Long-term carcinogenicity studies have not been conducted to evaluate the carcinogenic potential of fidaxomicin.
The CCCTC-binding factor plays critical roles in genome topology and function, increased risk of carcinogenicity, and potential of lung cancer-specific mediations.
Seventy-five of the rodent mammary carcinogens fall into 17 groups, based on exposure potential, carcinogenicity, and structural similarity.
Butadiene is carcinogenic in mice and rats, which raises concern for potential carcinogenicity in humans.
Data from the Salmonella assay were used by Ashby (1985) to identify structural alerts for potential carcinogenicity, providing critical data for the development of computerized structure activity methods for carcinogenicity prediction (Richard 1998).
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