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Under this novel model, cessation of exposure could arrest or reverse the carcinogenic process.
The results are highly suggestive that functional alterations of these genes may be causally related to the carcinogenic process.
The initial chemical reaction that produces a mutation does not in itself suffice to initiate the carcinogenic process in a cell.
Cox-2 inhibitors represent an approach to interdict in the carcinogenic process".
Intestinal-type gastric cancer shows a multi-step carcinogenic process, from atrophic gastritis to intestinal metaplasia to dysplasia.
Since the objective of this study was to explore the candidate genes involved in the carcinogenic process for further studies, this study is considered a preliminary step.
The functional involvement of individual genes or pathways in the carcinogenic process needs to be further studied individually to determine their actual involvement.
Dysregulation of TGF-β signaling has been implicated in the carcinogenic process in many organs.
Recently ChoKα has been implicated in the carcinogenic process, since it is over-expressed in a variety of human cancers.
Indeed, KRAS is mutated in nearly 50% of tumors at a relatively early stage of the carcinogenic process [72].
This represents the first report that Ets1 can play a major role in the early stages of the carcinogenic process.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com