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The apparent resistance of OC to further biotransformation in the human body (He et al. 1999) and the limited biodegradation reported in carbon dioxide evolution tests (EMEA 2005), plus its structural similarity to the environmentally persistent NA inhibitor Relenza, strongly suggests that both Tamiflu and OC will persist in wastewater and river water.
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The only published account of the biodegradability of Tamiflu is within the documentation submitted by Roche to the EMEA (2005) in which it refers to the OECD carbon dioxide evolution test (Modified Sturm test) that investigates the mineralization of Tamiflu in an aerobic slurry enriched with sewage sludge.
carbon dioxide evolution rate.
With butane there is little carbon deposition and there is low level carbon dioxide evolution between 423 and 873 K [9].
In Fig. 9, both the carbon dioxide evolution profiles for the normal and extended bed are compared.
Carbon dioxide evolution (CER) and oxygen uptake rate (OUR) were calculated from continuous measurements of carbon dioxide and oxygen.
Carbon dioxide evolution rate (CER) profiles for incubations T1 and T6 are shown in Fig. 1.
The cumulative carbon dioxide evolution rates (cCER) for all treatments are shown in Table 5.
YDM = yeast dry mass; glc = glucose; nd = not detected; OUR = oxygen uptake rate; CER = carbon dioxide evolution rate.
If no change in carbon dioxide evolution rate (CER) was observed, the concentrations of inhibitors were increased.
Besides H2 formation, carbon dioxide evolution occurred during the first heating cycle in methane up to ~700 K.
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