Your English writing platform
Discover LudwigExact(3)
Analogs with sterically hindering isopropyl and phenyl substituents on the benzylic carbon connecting the aromatic core of W1400 to the acetamidine nitrogen, showed good inhibitory potency for nNOS (IC50 = 0.2 and 0.3 μM) and selectivity over eNOS (500 and 1166) and to a lesser extent over iNOS (50 and 100).
The 13C NMR showed the two benzyl methylene carbons at 34.8 ppm while the methylene carbon connecting the two triazole moieties appeared at 60.0 ppm.
The information obtained from 2D NMR experiments concerning the proton and carbon connecting scheme in the studied compounds has enabled their structures to be confirmed and finally proven.
Similar(57)
The amorphous carbon connects the Si nanoparticles with SEG to form a 3D conductive network.
all remaining environment carbons (on heteroatoms and carbonyls) are replaced by the "R atoms"; exceptions are environments on single atomic N or O FGs with one carbon connected, where this carbon is retained also with its type (aliphatic or aromatic), this allows to distinguish between amines and anilines, and alcohols and phenols. .
It has been well acknowledged that all of these monomers are in the (R --configuration if they have chiR --configuration caR --configurationthe hydroxyl group (Gangoifi ethey. [2010]; Lee [1996]; Lee et al. [1999]; Liu et al. [2007]; Matsumoto et al. [2013]; Park et al. [2004]; Romano et al. [2005]; Ruthave al. [2007]; Steinbüchiralnd Valentin [1995]).
Therefore, the intense signal at 288.2 eV indicates the presence of peptides in fraction 3. Peaks at 285.1 eV and 285.4 eV may be assigned to π*C=C states of aromatic carbon connected to C or H [26, 27, 29], whereas the peak at 287.0 eV may be attributed to C-1s → π*C=C transition of aromatic carbon bound to an O atom [28].
d) MACCS 138: An aliphatic carbon connected with 3 atoms of which one atom is not the carbon or hydrogen, second is any atom and third is with 2 further hydrogen's.
acetal carbons, i.e. sp3 carbons connected to two or more oxygens, nitrogens or sulfurs; these O, N or S atoms must have only single bonds.
In the present algorithm we restricted our definition only to classical acetal, thioacetal or aminal centers (i.e. sp3 carbons having at least 2 oxygens, sulfurs or nitrogens as neighbors) and did not consider other similar systems, i.e. alpha-substituted carbonyls or carbons connected to S=O or similar bonds.
With three or more "linear" aliphatic carbons connected to the piperidine ring nitrogen atom, it appears that the steric hindrance of the bulky substituents of 4-aminopiperidine drugs may be avoided because of these flexible linkers.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com