Sentence examples for car specificity from inspiring English sources
CAR specificity is frequently determined by a single-chain variable fragment (scFv – the targeting domain), which is formed by the self-association of cloned variable regions of heavy and light chains of a monoclonal antibody (Fig. 3).
Chimeric antigen receptor (CAR) endows specificity to T-cells independent of human leukocyte antigen (HLA).
The overall rate of correct classification, employing the usual 0.5 cutpoint, is estimated as 76.3%, with 91.7% correct classification of car choice (specificity), but only 28.5% correct classification in the group that actually choose the e-bike (sensitivity).
This curve is obtained by plotting the probability of detecting a true e-bike choice (sensitivity) and a car choice (1-specificity) for an entire range of possible cutpoints.
"But when I went to Nic to talk about car engines and the specificity of the kind of cars they were, he said, 'I don't even have a driver's license and I've never driven a car.
Open image in new window Figure 2 Antigen A AND antigen B combinatorial antigen recognition to optimize the specificity of CAR T recognition and reduce the "on-target/off-tumor" toxicity.
One such option may be to separate the antigen for specificity of CAR T cells with the chimeric costimulatory receptor engaging a separate antigen.
In addition, CD123-CAR-VST retained the specificity against CD123-positive AML cell lines such as MOLM13 and THP-1 in vitro.
Chimeric antigen receptors (CARs) redirect T cell specificity toward antibody-recognized antigens expressed on the surface of cancer cells, while T cell receptors (TCRs) extend the range of targets to include intracellular tumor antigens.
Treatment with D-CAR T cells exhibited specificity for β-glucan which led to damage and inhibition of hyphal growth of Aspergillus in vitro and in vivo.
