Sentence examples for car activation in from inspiring English sources

These characteristics make the studies of CAR activation extremely challenging and pose major difficulties for evaluating drug-mediated CAR activation in vitro.

Our data thus indicate that CAR activation in some aspects mimics the effect of insulin on the liver.

Most recently, CAR activation in mice was shown to decrease circulating HDL, probably by down-regulating ApoA-I gene expression [ 19].

Thus, new findings in this report link an important role in CAR activation that is dependent upon oxidative stress.

Recently, the p38 MAPK was identified as a required factor optimizing CAR activation and CYP2B6 induction in liver cells (Saito et al., 2013).

Nonetheless, a definite role of p38 MAPK in CAR activation has yet to be established, given that activation of p38 MAPK appears to enhance some but not all target genes of hCAR.

CAR activation by TCPOBOP resulted in systemic dyslipidemia that includes lower serum LDL and HDL cholesterol and increased triglycerides (Additional file 2).

CAR activation by TCPOBOP results in an increase of serum triglycerides due to increased hepatic fatty acid synthesis and lower fatty acid degradation.

Figure 4 shows that TCPOBOP and subsequent CAR activation did not increase the SREBP2 active form in the nucleus.

In summary, CAR activation by TCPOBOP leads to lower total serum cholesterol due to activation of the LDL uptake from the circulation and repression of HDL export.

In this regard, CAR activation can enhance the metabolism and toxicity of some drugs, such as acetaminophen (Zhang et al., 2002), and potentially increase tumor propensity by stimulating cell proliferation (Takizawa et al., 2011).