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The hasA gene product is essential for capsule production in both S. pyogenes and S. uberis [ 64, 65].
DHEA-mediated cell surface changes include alterations in: cell surface charge, surface hydrophobicity, capsule production, and carotenoid production.
Capsule production inhibits phagocytosis by macrophages.
We next sought biochemical evidence that C7 inhibited capsule production in UPEC K1.
Here we describe results that link copper homeostasis to capsule production and the inhibition of phagocytosis.
The mutant also displayed sensitivity to copper starvation and defects in polysaccharide capsule production and melanization.
Furthermore the hrk1Δ mutation did not affect increased capsule production of the hog1Δ mutant (Fig. 7A).
Chemical inhibition of K capsule production may achieve similar therapeutic results without most of these limitations.
However, the siaABC locus, which is required for capsule production, appears only in N. meningitidis.
In fact, we found that MPK1 controlled both melanin and capsule production in strain R265.
The hrk1Δ mutant displayed normal levels of capsule production comparable to the wild-type strain, whereas the hog1Δ mutant showed increased capsule production as previously described [5], [6], [8].
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