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In the case of Burkholderia pseudomallei the presence of the capsule is required to prevent complement factor C3b binding, an essential step in complement killing [ 71].
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In addition, adequate nutrient supply to the capsules is required to maintain cell viability.
Dissolution testing for pharmaceutical products in tablet and capsule form is required by the US Food and Drug Administration FDAandand increasingly used outside the USA to report on the quality of drugs.
The purpose of the 2 studies presented in this article was to determine the clinically appropriate dose of doxercalciferol capsules that is required to maintain similar intact parathyroid hormone control when converting from intravenous (IV) paricalcitol or doxercalciferol.
This suggests that there are different signaling pathways that feed into capsule production, and that Rim101 is required for capsule attachment in one condition but not the other.
Reduced temperature increased the forces required for capsule puncture however further work is required to confirm its significance.
However, the siaABC locus, which is required for capsule production, appears only in N. meningitidis.
To test the hypothesis that inositol is required for capsule formation and that mutation of two major fungal inositol transporters (Itr1a and Itr3c) may result in an altered capsule structure, we measured capsule size and GXM secretion in the wild type and itr1aΔ itr3cΔ mutant under conditions with different inositol levels.
As an in-frame deletion in hvyA (Δ hvyA) phenocopied the buoyancy defect of Δ pleC cells (yielding exclusively 'light' mucoid cells, Figures 1b, 2a, 2b), we conclude that HvyA is required for capsule-mediated buoyancy control in Caulobacter.
Limited dissection outside the capsule to form a working space is required, but aggressive dissection is harmful for tissue healing although it is helpful for visualization and instrumentation.
We further test whether C. gattii calcineurin is required for melanin and capsule production.
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