Release of KCl from cellulose capsules was comparable to extended release capsule formulation.
The bioequivalent capsules were interchangeable with respect to C max), C trough), and AUC at steady state and also on conversion from one capsule formulation to the other.
Thus, it is not recommended to start with a simple capsule formulation as service dosage form and to change later to a market ready tablet formulation.
In vitro drug release of the nanoemulsion formulations was highly significant (p < 0.01) as compared to marketed capsule formulation and drug suspension.
A sprinkle capsule formulation containing enteric-coated, delayed-release rabeprazole granules is being developed for the treatment of children with gastrointestinal reflux disease.
The capsule formulation demonstrated a faster absorption into the blood circulation, including a superior metabolization of ezetimibe into the active glucuronide conjugate.
A clinical trial of (2S -2-[4-[[ 3S -1-acetimidoyl-3-pyrrolidinyl]oxy]phenyl]-3- 7-amidino-2-naphtyl) propanoic acid (DX-9065) revealed that its oral bioavailability was only 3% when it was administered as a conventional capsule formulation.
An immediate-release, multiparticulate capsule formulation of tizanidine has been developed to modify tizanidine pharmacokinetic characteristics in an attempt to decrease adverse events (AEs) while maintaining effectiveness in the management of spasticity.
The methodology was able to discriminate between capsules produced using different primary materials i.e. gelatin versus hypromellose, as well as more minor changes to capsule formulation i.e. different material grades and excipients.
Oral bioavailability of DX-9065, a factor Xa inhibitor, was only 3% when it was administered as a conventional capsule formulation in fasted humans, and was further reduced to about one-tenth when it was administered to fed humans.
Purpose: This study was designed to develop and validate two simple, rapid, and economical UV-spectrophotometric and the first-order derivative methods using the area under curve method for estimation of diacerein in bulk and in capsule formulation.
