Sentence examples for capping function from inspiring English sources

Loss of telomere capping function brought about by telomerase deficiency and gradual erosion of telomere ends or by experimental disruption of higher-order telomere structure culminates in the fusion of defective telomeres and/or the activation of DNA damage checkpoints.

Prkdc is also involved in telomere maintenance and in contrast to mice genetically engineered to lack Prkdc (i.e. null mutants), which show complete absence of DNA-PKcs activity, loss of telomere capping function and normal telomere length, cells from scid mice show not only loss of telomere capping function but also abnormally elongated telomeres.

It is noteworthy that the telomere lengths in SCNT cloned embryos are significantly lengthened, and the capping function of telomeres in Terc−/− ntESCs is enhanced.

However, the telomere is a complex nucleoprotein structure where, for example, it has been estimated that greater than 40 proteins are involved in the capping function alone[56].

Mutation p.His137Asp introduces a negative charge in the region and, in our simulations, Asp137 does not exert a capping function, but strongly interacts with Lys104 by making a salt bridge.

It is unclear whether telomerase has a capping function that is independent from its telomere elongation activity.

Genes of interest included those that encoded: chromodomain-containing proteins; chromatin-associated proteins; proteins involved in nuclear structure including nuclear attachment and nuclear pores; and, proteins already known to be associated with telomeres or involved in telomere capping functions.

Thus, Rap1p and the associated Rif1p and Rif2p proteins have important capping functions outside of S phase with Rif1p and Rif2p making specific and separable contributions to this capping.

However, given that members of the Cdc13 complex interact with components of the lagging strand machinery, it is also possible that the capping functions of the Cdc13 complex are directly associated with the passage of the replication fork (Nugent et al. 1996; Qi and Zakian 2000; Grossi et al. 2004; Vodenicharov and Wellinger 2010).

Potential candidates include Eps8 or twinfilin (Carlier and Pantaloni, 2007), although it should be noted that none of these factors are capable apparently of compensating for an essential aspect of capping protein function in lamellipodium protrusion revealed by RNAi (Mejillano et al, 2004).

Pause, A. et al. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function.