Where genomics and proteomics capitalize on sequence-based signatures, glycerophospholipids lack easily definable molecular fingerprints.
Where genomics and proteomics capitalize on sequence-based signatures, lipids lack such easily definable molecular fingerprints.
Variations from the reference genome are identified and annotated, and by capitalizing on sequencing depth of coverage between samples, alterations to the normal diploid genomic state can be identified and changes in copy number recognized (reviewed in [ 12]).
To capitalize on the virus-sequencing project he'd begun halfway through his Ph.D., Kouzarides did a short postdoc with Barrell.
The spotted gar represents a sister group of the teleosts, as we showed using genetic maps that capitalize on massively parallel DNA sequencing (Amores et al. 2011), novel software to analyze these sequences (Catchen et al. 2011a), and bioinformatic algorithms to perform comparative genomics (Catchen et al. 2011b).
Apparently, these approaches are not optimal to capitalize on the potential provided by sequence data.
Our TAS approach (for targeted genes) and the multiplexing PCR approach of Stiller et al. (2009) (for mitochondrial genome sequencing) both capitalize on the PCR amplification of target DNA (often degraded and/or fragmented) and couple this with the power of next-gen sequencing.
The Anopheles project has been fortunate to leverage all of these resources, allowing it to produce quality reference assemblies for important vectors of malaria and fully capitalize on the research potential of inexpensive sequencing data.
Recently, methods for estimating mutant abundances in complex mixtures have been introduced that capitalize on advances in high-throughput quantitative DNA sequencing.
NGS platforms capitalize on parallel processing to generate hundreds of megabases of sequence from a single run allowing for deep coverage of vast regions [ 3].
The question then becomes how can we capitalize on the next-gen platform to accommodate this targeted gene sequencing for a large volume of samples?
