Exact(13)
Another TEG parameter, K time, showed insignificant differences between the normal controls and different CAPE concentrations.
These CAPE concentrations were selected because they led to significant changes in DD levels.
In this study, the dose response curve showed a range of CAPE concentrations.
Therefore, variabilities in fibrinolytic effects may be yielded, which is hoped to be overcome when high CAPE concentrations are used.
There was a statistically significant reduction in postincubation clot weight compared to preincubation clot weight using the different CAPE concentrations.
However, no significant differences in weight were observed among samples incubated with different CAPE concentrations, although significant weight reduction was observed in some of the groups.
Similar(47)
Incubation with 22.50 mM CAPE led to higher DD levels (peak), which declined progressively with increased CAPE concentration.
The median WB clot weight post-CAPE incubation was significantly lower than the median pre-CAPE incubation clot weight for every CAPE concentration tested.
The relationship between DD level and CAPE concentration was nonlinear above 22.50 mM CAPE, most likely because of the rate-limiting effects of the fibrinolytic enzyme.
The confocal microscopy which detects structural changes of fibrin may be influenced by many factors including CAPE concentration, buffers, dyes, and WB clot size used for confocal microscopy.
The fibrinolytic activity of CAPE at different concentrations was measured using a previously reported method, which was used to demonstrate that CAPE has time-dependent fibrinolytic activity at 3, 6, and 9 hrs [ 30].
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