Absence of CD81 on hepatocytes merely prevents productive infections but it does not alter the capacity of sporozoites to traverse hepatocytes (Silvie et al, 2003).
We have previously shown that development of P. berghei parasites lacking P36P is aborted early after sporozoite invasion of the hepatocyte, whereas gliding motility and the capacity of these sporozoites to traverse and invade hepatocytes is not affected.
These epistatic interactions play key roles in determining the specificity of binding by each TF, and they strongly shape the functional topology of the joint sequence space and the capacity of each molecule to traverse this space under various evolutionary scenarios.
The higher frequencies give the signal information-carrying capacity, the lower ones some ability to traverse walls.
When examined in vitro, WT-F and ZIPCO-F sporozoites had similar gliding capacities on glass slides (Supplementary Fig S3A), and no differences were observed in their ability to traverse and invade host cells in vitro (Supplementary Fig S3B).
New Hampshire is easy to traverse.
Who wants to traverse that steep Appellation Trail?
Then he had managed to traverse several Alpine passes.
Backup forces would need to traverse hundreds of miles.
Stronger tornadoes tend to traverse a corridor across central Alabama.
