These mutants would potentially produce false-negative test results in susceptible HBsAg immunoassays and yet have the capacity to replicate in a manner similar to that of wild-type virus.
In addition to its capacity to replicate in a large number of mosquito cell lines, LNV is the only seadornavirus that replicates in a variety of transformed or primary mammalian cell lines such as Hep-2 (human carcinoma cells), BGM, Vero, BHK-21, L-929, and MRC-5 (human lung fibroblasts).
Furthermore, the presence of subpopulations of tumor cells that differ in their genetic makeup, metastatic potential, invasiveness and capacity to replicate may further compromise an already complex signature, in that the most clinically relevant signature may be masked by a 'non-lethal' signature that dominates the tumor's DNA or RNA sample.
Normal cells have a limited capacity to replicate, and so they age and die.
Consequently, during nutrient depletion, cells harboring the RAS2val19 mutation may enter S phase with a reduced capacity to replicate DNA.
Strategies to circumvent these limitations have involved the use of other adenovirus types that have a better capacity to replicate in vivo.
Clearly these barriers to infection are not absolute since Vs virus (SIB TBEV) has a limited capacity to replicate in I. ricinus (Fig. 5).
This replicometer, in combination with the discovery of the enzyme telomerase, has gone very far in explaining why most normal somatic cells have a finite capacity to replicate both in vivo and in vitro and how immortal cancer cells circumvent this inevitability.
Loss of telomere length limits a cell's capacity to replicate.
Innovation and performance can be enhanced if the actors occupy central network positions that provide access to new knowledge developed by other units, even though it may be dependent on an individual's capacity to replicate new knowledge (Tsai 2001).
Once attached to bone, the mononuclear osteoclast precursor fuses with its sister cells to form a terminally differentiated polykaryon, which no longer has the capacity to replicate.
