To test our working hypothesis, we analyzed both the functional profile of Mtb-specific CD4 T-cell responses and the presence of Mtb-specific CD8 T-cell responses in 194 subjects diagnosed with active tuberculosis or LTBI, and performed multivariate regression analysis to assess their relative or combined capacity to distinguish active tuberculosis from latent infection.
First, de novo protein design has complicated the assertion that biological function is equivalent to biological structure — demonstrating the capacity to abstract active sites from natural contexts and paste them into non-native topologies without loss of function.
Nevertheless, the major drawback is that it lacks capacity to differentiate active BoNTs from the inactive toxins.
For example in one community substance use or domestic violence may limit parental capacity to provide active supervision for children and youth, yet in another location the contributing mechanisms may instead simply reflect poor awareness of the risks in the local area.
These results show that embryonic tissues express key circadian genes and have the capacity to express active circadian regulatory cycles.
Equally, we have no data on the respondent's workplace and are thus unable to assess the workplace's capacity to support active travel.
Participants seemed to suggest that good communication and involvement in the treatment process equipped TB patients with the capacity to play active roles in managing their own health.
Effective participation and protection of young people in transitional justice processes, when properly supported and guided, can build their capacity to be active citizens and help break the cycle of violence and conflict.
The factory is not expected to have capacity to produce active pharmaceutical ingredients (APIs) – so-called "primary manufacturing" -, but 21 generic drugs are planned to be produced through mixing raw materials and packaging – secondary and tertiary production [ 5].
In our conceptual framework, we also incorporate six categories of control variables that may influence an individual's capacity to take an active role in managing their health and experience increased patient activation (participant age, gender, race/ethnicity, census tract poverty, cognitive functioning, and health status) [ 11].
