Sentence examples for capacity to activate the from inspiring English sources

While the NF-κB pathway is a central player in inflammatory signal transduction, IL-1 and TNF also share the capacity to activate the stress-activated protein kinase/c-Jun N-terminal kinase and p38 mitogen-activated protein kinase, as well as others [ 32, 33].

The crystal structures of the estrogen receptor α (ERα) ligand-binding domain bound to 17β-estradiol (E2) and E4 are very similar, as well as their capacity to activate the two activation functions AF-1 and AF-2 and to recruit the coactivator SRC3.

Different groups have previously reported that FADD, besides its capacity to activate the classical caspase cascade activation, may also trigger a non-apoptotic form of cell death [26], [27], [28], [29], [30].

In contrast, 60% of the ESR1-negative tumours (group B), which show the highest expression of NFκB2 and RELB, harboured missense mutations in BRCA1, which could produce aberrant proteins but conserving some activities such as the capacity to activate the NF κB machinery.

Interestingly, KLK4 has the capacity to activate the proform of the urokinase-type plasminogen activator (pro-uPA) and to modulate the activity of its receptor uPAR, both of which play a significant role in prostate and ovarian cancer [48,49].

We believe that the design of membrane-mimetic films that have the capacity to activate the protein C pathway will provide a useful strategy for generating "actively" antithrombogenic surfaces.

However, other factors, such as significant differences in the IgG isotype distribution in the two groups could interfere with the interpretation of this result, since different immunoglobulins have different capacities to activate the CP.

We have therefore studied different oat cultivars in in vitro and ex vivo models of celiac epithelial activation and compared the capacity to activate this pathway with the oat protein profile.

The hypercoagulable state is due to enhanced intrinsic contact activation and reduced capacity to activate protein C. The coagulation system might be a useful additional therapeutic target to reduce the high recurrence rate of stent thrombosis.

To investigate a potential correlation between the high levels of anti-LTSRPA antibodies in sera of patients with rheumatoid arthritis (RA) and the perpetuation of the immune response characteristic of this disease, we analyzed their capacity to activate complement and the process of binding to the serum lectin mannan binding protein (MBP).

In addition, ORF4 mutant viruses with a reduced capacity to activate Akt showed the same phenotype, and activation of Akt by insulin was able to release this phenotype to a significant extent, thus providing further evidence for a role of Akt activation in promoting infection.