Skeletal muscle inherently has a high regenerative capacity in response to injury but this capacity is overwhelmed in the case of volumetric muscle loss (VML).
But its refining capacity is overwhelmed: Mexico must import more than a quarter of its gasoline.
Based on these observations, we hypothesized that when ER folding capacity is overwhelmed, IRE1 initiates endonucleolytic cleavage of mRNA encoding insulin, the major secretory protein in pancreatic β-cells.
When autophagic capacity is overwhelmed, apoptosis is promoted in cancer cells (Maiuri et al, 2007).
This may explain why their reparative capacity is overwhelmed by factors occurring during high-speed exercise, including various potential combinations of high levels of mechanical strain, hypoxia, ischemia-reperfusion events, and hyperthermia (due to hysteresis in energy-storing tendons) [ 16- 20].
In parallel, the second pathway might also start as a reversible, adaptive response that leads to a chronic adverse health effect when the physiological repair capacities become overwhelmed.
In many human diseases, especially metabolic and neurodegenerative disorders, cellular folding capacities are overwhelmed by increased protein synthesis rates and/or accumulation of abnormal proteins, resulting in ER stress-mediated cell toxicity or death (Lin et al., 2008).
Not only are the hospitals' capacities often overwhelmed by the massive and unexpected load of patients, but the patients must be triaged and treated in an austere environment where delayed referral is a common phenomenon.
In an unexpected burst of enthusiasm in The Trouble With Being Born, EM Cioran declares that everything by Emily Brontë "has the capacity to overwhelm me.
"We won one," he said of the 1-0 victory at Hampden Park in 1985 but he, too, is almost misty-eyed at the occasion's capacity to overwhelm.
