Sentence examples for capacity of differentiating from inspiring English sources
Bone marrow-derived mesenchymal stem cells (BMMSCs) from the patients suffering from age-related osteoporosis were found to have numerous degeneration, such as decreased growth rate, impaired capacity of differentiating into local tissue, and repressed telomerase activity.
The discovery that teeth contain a small sub-population of stem cells endowed with the capacity of differentiating into the individual cellular components required to regenerate the pulp tissue provides the scientific rationale for the field of dental pulp tissue engineering.
Micro-environmental heterogeneity might also be expected to interfere with any intrinsic self-organizational capacity of differentiating hESC.
We next examined whether MMSCs possessed the capacity of differentiating into various lineages compared to that of BMSCs.
Previous studies have shown that NB cells exhibit a capacity of differentiating into mature cells or spontaneous regression by apoptosis [ 92, 93].
They have the capacity of differentiating into multiple cell lines, such as adipocytes, osteocytes and chondrocytes, even other cell types besides mesoderm lineages.
Eventually the cells fail to differentiate, suggesting there may be more to the loss of capacity to differentiate with increasing passage than TGFβ-mediated mesenchymal transition alone.
While TGFβ mediated-EMT plays a dominant role in the loss of RPE phenotype with increasing passage, our results suggest that there are other passage-dependent processes that contribute to loss of capacity to differentiate.
In the last years, MSCs have attracted attention for their capacity, under proper culture conditions, of differentiating into a variety of mesodermal lineages, including fibroblasts, chondrocytes, osteoblasts, and adipocytes.
MSCs are present in adult tissues and their involvement in repair mechanisms has been demonstrated as the result of their ability to migrate towards sites of injury, their capacity to differentiate into tissues of mesodermal origin (adipocytes, osteoblasts, and chondroblasts), and their immunoregulatory properties [ 4].
CMs differentiated from PSCs have unquestioned cardiomyogenic potential, in contrast to various adult stem cells, of which the capacity to differentiate into significant numbers of definitive CMs is controversial.
