More importantly, as a proof-of-concept we report that in these pro-proliferative conditions, pharmacological inhibition of EZH2 by two different approaches, i.e. by decreasing its availability or hampering its activity, is capable to prevent the proliferation and allow the recovery of myogenic differentiation of these cells in vitro and in vivo.
Two different ways for CML cells to adapt to hypoxia were also evidenced: a "rapid adaptation" (occurring within 1 day of incubation in hypoxia) of cell bulk emerged, capable to prevent BZ-induced caspase activation, apoptosis and BCR/Ablprotein suppression, and the consequent destruction of culture.
Nevertheless, BMP7 is a gene that appears to corroborate this concept since it is described as promoter of normal osteoblast function [ 39, 40] and capable to prevent atherosclerosis [ 41, 42].
This is in line with previous evidence that NMDA receptor antagonists are capable to prevent UCB-induced neurotoxicity, both in vivo [31] and in vitro experiments [32], [33].
We further show that miR-17, -20a, and -106b act in a pro-proliferative manner in USSC and are in part capable to prevent XXL-USSC from cell cycle arrest.
Medicinal plants comprise vast range of organic substances which are capable to prevent most of the diseases related to oxidative stress [ 10] and these plants are commonly used in the folk medicine for treatment of many diseases [ 11].
Therefore, the competitive and cooperative PSO with ISM (CCPSO-ISM) is capable to prevent the premature convergence when solving global optimization problems.
During the guillotine break of cooling system, the burst disc opens, but pressure increase protection system is capable to prevent overpressure of the vacuum vessel.
We have already demonstrated that NAC pre-treatment is capable to prevent apoptosis in renal cells.
Ranolazine was capable to significantly prevent progressive left ventricular dysfunction as well as global and cellular myocardial remodeling.
