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Indeed the recent crystal structure of isolated Hsp70 substrate binding domain with unfolded peptide mimics (Zhang et al., 2014) indicates that the substrate binding domain alone is also capable to bind unfolded peptide substrates.
The ligands, capable to bind the metals, thus, reducing their concentrations, appear to be a part of the resistance mechanism.
The application of the IMS technique implies that the matrix polymer must bear some functional groups (e.g., sulfonic or carboxylic) capable to bind metal ions (PSMNP precursors).
Lack of efficacy was based on a failure to induce antibodies capable to bind epitopes in the context of functional OPN protein.
Nevertheless, Cyt1Aa was capable of Cry11Aa binding only when displayed in ribosomes (Fig. 5b) in contrast when displayed in M13 where it was not capable to bind Cry11Aa (data not shown).
The use of new forms of nanocomposites that are capable to bind to CSCs and induce tumor destruction as the EC is a promising direction the treatment of oncopathology. 1.
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We found that DC-Chol-containing liposomes are capable to strongly bind influenza vaccine antigens upon simple mixing with the vaccine.
Like other sirtuins, SIRT1 is not capable to directly bind to DNA but needs to be recruited by a variety of chromatin-associated factors to their binding sites.
However, it is unclear at present which desmosomal cadherin isoforms are capable to heretophilically bind to each other and thus interpretation of these distribution patterns with respect to their relevance for mechanical adhesion is preliminary.
For instance, HECTAm1 contains PH and SPRY motifs, and HECTHe1 and HECTEx1 have Laminin-G3 (capable to reversibly bind to specific complex sugars, an exclusive feature of these two families) and SPRY domains.
Finally, it is shown by an experiment that this approach provides a real-time capable way to bound the unmeasurable states of an induction machine.
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