We then produced transgenic lines and crossed them into the BicDnull mutant background [20] to test whether the mutant alleles were capable to substitute for the normal BicD in the various processes described.
However, the conserved histidine residue present in the WH domain of NALP2, NALP4, and NOD1 may still be capable to substitute the function of Sensor 2. The GxP signature is a conserved motif located in the small helical subdomain (C-domain) [18] at the C-terminal region of the NACHT domain (Figure 1) [19].
These results show that both the amino-terminal and the carboxyl-terminal domains of Hydra Myc2 are principally capable to substitute for the corresponding regions in the highly oncogenic retroviral v-Myc protein, although the overall transforming potential of Myc2 is lower than that of Myc1.
The use of substances capable of substituting the material responsible for greenhouse gases can reduce global warming, which is caused by the emission of greenhouse gases into the atmosphere, especially CO2.
Two copies of the chicken β-globin insulator (ChβGI 2 are capable of substituting for the enhancer blocking function of the ICR.
However, TatE is capable of substituting for TatA [46], although the structures of TatE complexes are very different to those of TatA complexes [12].
Finally, we found that signalling pathways mobilised by either the Met2P or Met2S receptors were equally capable of substituting for the WT pathways in regulating MN survival.
In this context, our present TatAd complex data are of interest because, like E. coli TatE, TatAd is fully capable of substituting for E. coli TatA [24].
In support of a critical role for Akt in stem cell regulation, constitutive activation of Akt was shown to be capable of substituting for basic fibroblast growth factor 33 or leukemia inhibitory factor to maintain stemness.
