While the presence of a DNA-binding partner appears necessary for transcription regulation, we cannot rule out the possibility that the biological function of Cass2 itself may be to provide a self-contained low-level multidrug resistance system, capable of sequestering drugs and preventing them from reaching further intracellular targets.
Self-assembling amphiphilic peptides and peptidomimetics can produce lipophilic domains capable of sequestering small molecules and acting as vehicles for drug delivery.
Our findings suggest that Borrelia spirochetes may be capable of sequestering within keratinocytes and fibroblasts, causing both persistent infection that is refractory to antibiotic therapy and aberrant fiber production by these infected cells in MD patients.
The hydrophobic polystyrene core domain is capable of sequestering hydrophobic molecules, and the hydrophilic acrylic acid shell allows for multivalent functionalization, such as cross-linking, complexation with small cationic ions/molecules, or conjugation with chromophores or radiolabels for visualization in vitro or tracking in vivo.
Experimental results indicated that the most reactive materials were capable of sequestering between 77% and 93% of the available carbon under experimental conditions in four hours.
Evidence also suggests that the postmenopausal breast is capable of sequestering and/or synthesising progesterone and estrogen from circulating hormonal precursors [ 21– 25].
Metal-oxides and clay minerals are important sinks for metal sorbates in soils and sediments, capable of sequestering these elements through various sorption reactions that control their speciation, solubility, and availability for transport and biotic uptake [1, 2].
Recombinant AChE and BChE capable of sequestering OPs in vivo have been successfully produced in transgenic goat milk, mammalian cells and plants9,10,11,12.
Thus, a tag capable of sequestering smaller metals would enable new tools and provide opportunity to expand therapeutic and diagnostic applications.
