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Limited differentiation has been shown capable of reversal and this may be a mechanism which leads to quiescence and associated "resistance", particularly in the case of AML.
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This protein family is capable of fork reversal and promotes recombination at stalled replication forks (Blackford et al. 2012; Gari et al. 2008; Nandi and Whitby 2012; Prakash et al. 2005; Schurer et al. 2004; Sun et al. 2008; Zheng et al. 2011).
This result indicates that although TWIST cannot sustain a full reversal of differentiation (cell cycle re-entry) in the absence of growth factors, it is capable of reversing the morphology of differentiated muscle cells.
Furthermore, just as one might take remedial action to untangle the cords under a desk, nature is capable of dramatic reversals: an extensively scrambled ciliate gene could become unscrambled in one step by fixation of a mutation that introduces the unscrambled macronuclear DNA into the micronuclear genome.
Development of therapeutic agents capable of prevention or reversal of carnitine deficiency in older adults may minimize the occurrence of frailty in geriatric populations.
The results show that a non-diffracting non-paraxial fractional Bessel vortex beam is capable of inducing a spin reversal of an absorptive Rayleigh sphere placed arbitrarily in its path.
Where once the system was thought to change, as it were, only glacially, now it is known to be capable of sudden and unpredictable reversals.
In general, applying higher voltage results in an increase of the damping coefficient by more than one order magnitude and significantly increases the minimal damping coefficient capable of being reached after field reversal.
At early stages, degenerating cones are capable of regenerating outer segments, indicating the reversal of the degenerative process.
This BAC transgenic line was capable of rescuing the XY gonadal sex reversal caused by complete loss of endogenous Map3k4 (data not shown).
We recommend that all laboratories seeking to build standard gene drives capable of spreading through wild populations simultaneously create reversal drives able to restore the original phenotype.
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