Even so, these results and the fact that increasing amounts of Tbx3 causes a gradual decrease in the promoter activity of PTEN imply that Tbx3 is capable of repressing PTEN and that this repression is specific.
Myc is capable of repressing its own gene, and this auto-repression is disrupted in all cancer cell lines tested [14], [15].
They knew from experience that the makhzen – the political-economic-security nexus that rules the country behind the scenes – would not yield power easily, and is capable of great repression.
With a luciferase reporter driven by the Cyclin A promoter, it can be shown that RB, RB-K and RB-N are each capable of transcription repression (Fig. 2A).
In agreement, two CRY1 mutants unable to coordinate zinc, C414A and H473A, were also capable of transcriptional repression, even though their PER-binding activities are largely compromised.
Through the use of two well-defined systems specially engineered to analyze EZH2-mediated gene silencing in lymphocytes (Jurkat-FLP and primary CD4+ splenocytes), we demonstrate that EZH2β is capable of gene repression that is mediated by trimethylation of H3-K27, indicathat that EZH2β behaves as a histone code writer in a manner which is highly similar to the conventional EZH2α protein.
Signals from wounding are capable of overriding the repression and of effectively increasing PpCSP1 expression, resulting in activation of the reprogramming process.
In the first studies of MeCP2, abundant binding sites of this protein were found in genomic chromatin, and MeCP2 seemed capable of long-range repression [17].
The results of this analysis are shown in Figure 5A; they suggest that CbfA-CTD is capable of performing both repression and transactivation activities in the absence of the remainder of the CbfA protein.
However, the 280 bp pho1 + pr- yfp + construct is not capable of relieving Csk1 repression in Pi-starvation conditions – expression is not induced in response to Pi limitation.
