Sentence examples for capable of repressing from inspiring English sources

Even so, these results and the fact that increasing amounts of Tbx3 causes a gradual decrease in the promoter activity of PTEN imply that Tbx3 is capable of repressing PTEN and that this repression is specific.

To ensure that H3K27 trimethylation is limited only to the repressed target, PRC2 is capable of repressing its own enzymatic activity.

Myc is capable of repressing its own gene, and this auto-repression is disrupted in all cancer cell lines tested [14], [15].

A study by Kilmon and colleagues [ 46] demonstrated that macrophages regulate B-cell tolerance by secreting regulatory factors like IL-6 and CD40L and that macrophages from lupus-prone MRL/lpr mice are less capable of repressing Ig secretion coincident with reduced secretion of these repressive factors.

Among these compounds, only gastrodin was capable of repressing transplanted H22 ascitic hepatic tumor cell growth in vivo with low toxicity.

Similarly, the GTG3A GR mutant, which contains three mutations within the DBD, preferentially recognizes a thyroid hormone response element rather than GREs, yet is capable of repressing NF-κB-driven transcription27.

Lastly, nonsynonymous SNPs may affect nuclear accumulation of ELF3, which - like expression level polymorphisms described above - would result in variation of the amount of nuclear ELF3 [ 11] capable of transcriptionally repressing PIF4, and other targets.

Finally, the glucocorticoid receptor Nr3c1 is a central regulator of inflammatory responses, capable of transcriptionally repressing pro-inflammatory genes and of transcriptionally activating anti-inflammatory genes (reviewed in [ 76]).

Taken together, both pharmacological inhibition of LSD1 activity and depletion of its expression are capable of de-repressing the hTERT transcription in normal human fibroblasts, although the effect was not robust.

By interacting with diverse co-factors and catalyzing demethylation of mono- and di-methylated H3-K4 or K9, LSD1 is capable of either repressing or activating the target genes.

Transcription factors exhibit sequence-specific DNA-binding and are capable of activating or repressing transcription of downstream target genes.