Sentence examples for capable of internalization from inspiring English sources
GFP fused to either full-length or its NLS is capable of internalization in PC3 or 293 cells (ATCC) within 2 hours after the addition of fusion proteins.
Application of targeted and intracellular delivery of effector moieties requires antibodies capable of internalization, i.e., a receptor-mediated endocytosis via a variety of clathrin-dependent and clathrin-independent endocytic pathways.
Yet, much evidence supports the possibility of a reuptake of Aβ peptides into cells by endocytosis, and members of the lipoprotein receptor (LDLR) family [ 9], α7 nicotinic receptors [ 46], as well as scavenger receptor for advanced glycation end products (RAGE) [ 21, 56, 71] have all been reported to interact with Aβ and to be capable of internalization of extracellular Aβ peptides.
Recent studies report that clathrin- or caveolin-mediated endocytosis is capable of internalizing particles with diameters upward to 500 nm, yet internalization efficiency decreases with increased size.
Interestingly, the ascidian arrestin (Ci-arrestin, see Figure 1) has a clathrin-binding sequence and is capable of mediating internalization, similar to vertebrate β-arrestin [9].
One general finding of this work is that Krebs-2 ascites cells and human glioma cells are capable of dsDNA internalization and show some features of TISCs.
Taken together with the data of engraftment of TAMRA-positive Krebs-2 ascites, one can suggest that tumorigenicity of glioma cell fractions is largely attributable to the cells capable of dsDNA internalization.
We performed direct quantification of TAMRA-dsDNA internalization in squashed preparations of DAPI-stained neurospheres (7 neurospheres altogether), which indicated that about 20% of neurosphere cells were capable of internalizing dsDNA.
It is shown that SDBS and TX100 were capable of promoting cell internalization of MWCNTs and triggering higher oxidative stress, and thereby increasing the toxicity of MWCNTs; while HA could alleviate the toxicity of MWCNTs through limiting cell internalization of MWCNTs and reducing oxidative stress.
Pim inhibition in chronic lymphocytic leukemia is capable of increasing CXCR4 internalization, reducing surface re-expression and migration to bone marrow and spleen.
Collectively, these data suggest that only effector-competent anti-BDCA2 mAbs capable of mediating significant BDCA2 internalization, such as 24F4A, can lead to CD32a internalization.
