In particular, exposures during embryonic gonadal development and sex determination are capable of inducing adult onset disease states that can be perpetuated across multiple generations [1], [9].
Thus, presently BCV may be considered involved in the BRD complex, but the virus is probably not capable of inducing fulminate respiratory disease without the presence of other contributing factors.
Our major finding is that 1) Diminished PLG resulted in the enhanced amount and activity of PL in psoriasis; 2) PL is a potent cell activator, and is capable of inducing a psoriasiform skin disease that mimics human psoriasis with acanthosis, parakeratosis, subcorneal microabscesses, and dilated lymphatic vessels in mice.
It may be significant that, as shown in the PONDR® plot in Fig. 6, the A3 epitope that is capable of inducing spreading and autoimmune disease like the EBNA1 epitope shown in Fig. 5, is in a strongly ordered region located adjacent to regions of strong disorder of the PONDR® plot.
A major advance has come from the use of human uveal melanoma cell lines capable of inducing tumour growth and metastatic disease in immunodeficient hosts.
The central hypothesis of our understanding of PE is that it results from ischaemia of the placenta, which in turn releases factors into the maternal circulation that are capable of inducing the clinical manifestations of the disease [ 2].
Nevertheless, it clearly shows that a sudden increase in antibody response to a single CII epitope, as we have noted to occur spontaneously during the course of the disease, is capable of inducing severe arthritis.
Future efforts should be focused on the development of a well-tolerated formulation, capable of inducing strong immune responses in patients with premalignant HPV-induced disease.
Together with the previous studies showing a rapid decrease in cellularity after successful antirheumatic therapy (even in the absence of apoptosis), these data support the notion that therapeutic strategies aimed at interfering with retention of inflammatory cells at the site of inflammation might be capable of inducing clinical improvement in immune-mediated inflammatory disease.
It has been proven that radiotherapy is capable of inducing a local control rate of the disease up to 100% of cases regardless of the histologic subtype of the lymphoma and a low recurrence rate ranging between 0% and 15%.
