We thus conclude that DEGAS is capable of identifying small and focused modules that are more specific with respect to disease-related genes than those of jActiveModules, GiGA, BioNet or t-test.
This non-random association between a surrogate and a target's pharmacologically active site assures a high degree of probability that, once found, surrogates will have utility for the rapid development of SDAs capable of identifying small molecules of pharmacological importance.
Thus, shRNA libraries with greater diversity, and potentially greater "off-target" gene silencing, such as our random shRNA library, may provide greater genome wide coverage and increase the probability of identifying small RNAs capable of modulating complex cellular signaling pathways in a phenotype driven screen.
Although REAPR has a lower FPR (between 3% and 11%), it is only capable of identifying a small number of extensively misassembled contigs (between 2% and 14%) and a small number of locally misassembled contigs (between 2% and 27%).
In spite of the limitation, the inference analysis is capable of identifying a small subset of potentially affected diseases with interacting genes/proteins for experimental validation that greatly accelerates the hazard identification process.
If an imaging system is employed to detect all lesions in a patient, it must be capable of identifying the smallest lesions.
Our results indicate that 2D gel electrophoresis of the cytoplasmic membrane fraction is only capable of identifying a small proportion of the multi-pass membrane proteins in a given proteome, likely due to the low pI and poor solubility of these proteins [ 57].
The magnetic resonance imaging (MRI) with gadolinium enhancement is currently viewed as the most accurate diagnostic tool for VIII nerve schwannoma capable of identifying tumors as small as 3 mm in size.
Such reviews, or meta-analyses have greater statistical power to identify true effects from study-specific artefacts and, as such, are capable of identifying subtle effects that might be missed or deemed insignificant in smaller datasets.
For polarisable electrodes under small to medium steady-state current operation, the model was capable of identifying electrodes with the best kinetic or mass transport behaviour and classifying behaviour in terms of relative performance.
