Altogether these observations indicate that a 3D co-culturing model leads to an increase in the production of a number of molecules that are capable of stimulating aggressive invasive behaviour of cancer cells.
Noteworthy, over expression of Aurora kinase B in Chinese hamster embryonic diploid fibroblasts results in aneuploidy cells capable of forming aggressive tumors in nude mice [ 40] and Aurora kinase B is found over expressed in several solid cancers, including breast, colorectal, kidney, lung, and prostate cancer [ 27].
To reproduce, it's quite capable of giving less aggressive flora an elbow in the eye and a shove toward extinction.
"We believe that investment needs to be made in research for a new generation of screening and diagnostic tests - critically, ones capable of distinguishing between aggressive and slow-growing forms of the disease, the so-called 'tigers' and 'pussycats'".
From a mammary carcinoma spontaneously developed in HER-2/neu transgenic mice, we previously established a carcinoma derived mesenchymal tumor cell lineage, called A17 [18], capable of developing highly aggressive mesenchymal tumors when injected into syngeneic mice.
Unfortunately, there are no reliable histological parameters capable of predicting more aggressive behavior.
A major obstacle to improving patient selection is the absence of diagnostic tools capable of identifying biologically aggressive disease and predicting postsurgical recurrence.
Large skinks may be capable of eating more aggressive prey such as medium sized wolf spiders, or tomato hornworms.
As the cable television industry finally begins to deliver on the promise of its long-lamented digital upgrades and as DirecTV, the nation's No. 1 satellite television carrier, finally appears to be falling into the hands of aggressive and capable media operators, EchoStar and its mercurial chairman appear to face their biggest challenges in years.
Genetic markers capable of predicting increased risk of aggressive disease compared with increased risk of any prostate cancer diagnosis are urgently needed, due to the fact that predicting the outcome of prostate cancer is at present very difficult.
