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In all cases, highly charged polycation or polyanion were capable of aggregation suppression.
Numerous examples of other amyloidogenic proteins capable of aggregation individually, but showing a reduced rate of aggregation when combined in the same reaction, have been reported including prion proteins from different species [27] and different Aβ peptides [28].
Likewise, A β42 is capable of aggregation and misfolding leading to progressive neurodegeneration that develops insidiously over a lifetime.
Upon differentiation, cultures of MKs produced proplatelets and functional platelet-like particles (PLP) capable of aggregation and activation.
We report for the first time that upon differentiation LAMA-84 cells formed proplatelets and produced functional PLPs capable of aggregation and thus function as normal platelets.
Tau is intrinsically disordered proteins that is capable of aggregation, especially in the presence of lipid membranes and cause their disruption.
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Calcium ions are capable of promoting aggregation of purified OBs and are predicted to play an important role in OB aggregation and regulation during biogenesis processes [ 8].
All these conditions are capable of promoting aggregation and, on the background of normal aging, could enhance α-synuclein pathogenicity and ultimately have a role in neurodegenerative processes.
Both peptides are capable of assembling into amyloid fibrils in vivo, although Aβ42 is the more aggregation prone [97].
α-Synuclein is a highly soluble protein which in a nucleation dependent process is capable of self-aggregation.
α-Synuclein is highly soluble and a natively unfolded protein, which in a nucleation dependent process is capable of self-aggregation.
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