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Escherichia coli expressed proplasmepsin-2 is capable of activation at acidic pH by autocatalytic cleavage of the pro part region, which results in products of different length.
These particles were capable of activation and aggregation, thus proving their functionality.
In a control experiment, osmotic shock strongly activated all of the transfected p38 isoforms showing that all were efficiently expressed and capable of activation (Fig. 2D).
If the concentration of d-serine were to increase, it would decrease the activation effect of l-serine if it was not capable of activation itself (in Scheme 2, b > 1 > a).
As can be seen in Author response image 1, all DC populations (CD4+CD8-, CD8+CD4- and pDC) as well as macrophages were equally capable of activation Tg4 Teff as assessed by CD44 upregulation.
In normal endometrium expression of progesterone receptor (PR) is induced during the oestrogen-dominated proliferative phase and a number of response elements capable of activation by ERs have been described within the regulatory region of the PR gene [ 13].
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In further support of this idea, our previous work demonstrates that a Tax mutant, TaxM22, is capable of Tak1 activation despite its defect in IKK activation [ 34].
Early laboratory studies identified that RF was capable of complement activation via the classical pathway, suggesting that RF-immune complexes promote inflammation through complement activation [ 23].
Accessory/co-stimulatory molecules on the surface of T cells are capable of regulating activation signals.
The present study was designed to investigate if reactive oxygen species (ROS), similar to that generated in biological systems, are capable of oxidative activation of DCAN.
Conclusions: (1) Ischemia/reperfusion after coronary artery bypass grafting is associated with the release of factors capable of neutrophil activation from myocardium into the circulating blood.
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